The Student Handbook reiterates the general academic policies and information, as well as provides the following information:

1. Rules and Regulations on Student Conduct and Discipline
2. Revised Rules and Regulations Governing Fraternities, Sororities, and other Student Organizations
3. Guidelines on Accreditation of Student Organizations
4. Guidelines on Tambayans
5. Rules and Regulations Governing Activities of Student Organizations
6. General Guidelines for Posting
7. UP Manila Ratified Election Code
8. University Student Council Constitution
9. The Manila Collegian Constitution
10. Implementing Rules and Regulations of the Anti-Sexual Harassment Act of 1995
11. Republic Act 7877 (An Act Declaring Sexual Harassment Unlawful in the Employment, Education, or Training Environment and for Other Purposes)
12. Republic Act 7079 (An Act Providing for the Development and Promotion of Campus Journalism and for Other Purposes)
13. Republic Act 8049 (An Act Providing for the Development and Promotion of Campus Journalism and for Other Purposes)

Developed and maintained by the Office of Student Affairs, the latest version of the handbook in 2025 can be found here